Multiple Choice Question: 1 ´ 10 = 10

1. Molecules can be viewed with Phylip

1. Rasmol
2. ClustalW
3. OLIGO;

2. One of them is a genetic analysis software

1. ALLEGRO
2. pDRAW
3. pathDB
4. EXTNUM

3. Input file for Phylip should be in

1. FASTA format
2. GCG format
3. Flat ASCII format
4. Binary format

4. Restriction enzymes can searched using

1. AUTOSCAN
2. BETA
3. CROSSFIND
4. OLIGO

5. In ClustalW ‘:’ represents

1. Strongly conserved regions
2. Non conserved regions
3. Gapped regions
4. None of the above

6. Window size is increased for _______ sensitivity

1. Lesser
2. Greater
3. Create
4. None of these

7. Increasing tuple size ______ speed.

1. Decrease
2. Increase
3. Equalize
4. None of the above

8. Fasta format sequence begin with

9. ALLEGRO is the faster version of

1. ANALYSE
2. GENE HUNTER
3. ALLASS
4. None of the above

10. Insilico PCR can be carried out using

1. OLIGO
2. Molscript
3. Rasmol
4. Raster 3D

2. Why is RasMol background command used?
3. Write the use of RasMol connect command.
4. Define Current Oligo.
5. What is Priming Efficiency?
6. Name the MolScript directory distribution.
7. Write the action of -pretty.
8. What is ALSCRIPT?

1. At least one fourth of all values are at or below the lower quartile and at last three quarters of all values are at or above the lower quartile
2. Exactly one fourth of all values are smaller than the first quartile
3. The lower quartile is the collection of the smallest 25 percent of the data in the data set
4. One fourth of all smaller than the lower quartile and three quarters of all values are above the lower quartile 

2. The population variance is

3. Which of the following families of probability distributions is continuous and generally followed by the biological data?

1. Binomial
2. Poisson
3. Normal
4. Weibull 

4. The parameters that index the normal distributions include

1. mean and range
2. median and standard deviation
3. mean and standard deviation
4. median and variance 

5. Consider the list of marks obtained by the students of a class in the Science test. 10 6, 8, 2, 6, 7, 4, 6, 4, 5, 7, 9, 6, 1, 5, 3, 8. What is the correct procedure for obtaining the median of the given data?

1. The median is obtained by summing up all these numbers and dividing the result by the number of values
2. Since the number of values is 17, which is odd, the median is the middle number on the list
3. The median is the value that occurs most often
4. Data needs to be arranged in the ascending or descending order and then the middle value is called median 

6. Which of the following is not a parametric test?

1. t-test
2. ANOVA
3. Correlation Regression
4. Chi - squared test 

7. Roll a fair die twice. Let A be the event that the sum of the two rolls equals six, and let B be the event that the same number comes up twice. What is P(B/A)?

1. 1/6
2. 5/36
3. 1/5
4. 1/36 

8. The statistical power of a significance test increases with the

1. increased actual effect from the independent variable
2. increased sample size
3. increased level of significance
4. all of the above 

9. The total process of collecting, compiling and publishing demographic, economic and the social data pertaining at a specified time or times, to all persons in a country or delimited territory is known as

1. enumeration
2. census
3. notification
4. classification 

10. In one-way analysis of variance, the total variation is decomposed into:

1. Two components
2. Three components
3. Four components
4. None of these

Test whether there is any change in IQ after training programme. it is given that t_0.01=4.6 for df.

1. Exponential time algorithm is

1. O (n²)
2. O (n/2)
3. O (n*2)
4. O (2ⁿ)

2. Preprocessing involves using more standard techniques such as

1. Statistical analysis
2. Biological analysis
3. Mathematical analysis
4. Physical analysis

3. Data mining is also known as

1. OLAP
2. DSS
3. KDD
4. None of the above

4. T FASTA is for

1. DNA vs DNA
2. Protein vs DNA
3. RNA vs DNA
4. Protein vs protein

5. GCG program for Database searching is

1. String search
2. Type data
3. Assemble
4. Blast

6. PAM is

1. Point accepted mutation
2. Percent accepted mutation
3. PAM accepted mutation
4. Previous accepted mutation

7. Generally all software takes

1. GCG format
2. Ensemble format
3. NCBI format
4. FASTA format

8. The linear time algorithm is

1. O (mn)
2. O (mⁿ)
3. O (m+n)
4. O (m/n)

9. The version of BLAST is also known as gapped BLAST

1. BLAST 1
2. BLAST 2
3. BLAST 3
4. BLAST 4

10. How many open reading frames do you expect from a DNA sequence

1. Just one
2. Four
3. Three
4. Six

1. The quadratic time algorithm is usually __________ for a small problem.
2. _________ Technique is used to spot trends in data.
3. OLAP is ____________.
4. __________ is used to search databases for presence of conserved motifs.
5. ___________is a program for predicting genes in human sequence.
6. DSS is ______________.
7. _________ is the GCG program in multiple sequence alignment.
8. _________ is the GCG program for searching common motifs in a group of sequences.
9. Profile scan is based on classic _________ Method.
10. Blocks database uses concept of _________to identify a family of proteins.
11. Unweighted pair group method using arithmetic mean is a algorithm used for developing_________________.
12. Needleman - Wunsch algorithm is based _____________alignment.
13. The value K is used in converting a __________ score to a __________ score.
14. _____________is the interactive Macintosh program for manipulating trees and data and studying the phylogenetic behavior of character.
15. GATA repeat is an example of____________________. 

1. What are Blosum substitution matrices?
2. What is PROSITE?
3. Shortnote on Genscan.
4. Short note on SCOP and PDB.

1. What are the tools used for searching Database?
2. Define BLAST.
3. What are phylogenetic softwares?
4. What are the functional site in a DNA sequence and what are the programs to detect them?

1. DDL and DQL
2. DDL , DML and DQL
3. DDL,DML,DQL and DCL
4. None of these

2. How many types of Database Management System available

1. One type
2. Two type
3. Three type
4. None of the above

3. Purposes of Biological Databases

1. Data Mining
2. References of literature
3. Cross references
4. All of the above

4. worm_peptide is

1. Protein database
2. Nucleotide database
3. Sequence database
4. Structured database

5. Who Uses SQL

1. DBA
2. Application developer
3. End User
4. All of the above.

6. Aggregate Function consist of

1. SUM()
2. AVG()
3. MAX()
4. All of the above

7. How many rules given by Dr. E. F. Codd

1. 33
2. 12
3. 30
4. 6

8. What is the use of Index?

1. Rearrange the row in table.
2. To make view
3. Change the rowid of row.
4. Increase the speed of query

9. How many types of View?

1. 1
2. 3
3. 2
4. 4 

10. Alter command is use for

1. modify table structure
2. update record
3. Decrease column Size
4. all of the above

1. Unwanted rows can be deleted from the table using a ____________ statement.
2. The _____________ operator is used for pattern matching.
3. _______ and ______ are known as wildcard characters.
4. ______________ use SQL commands to define the database, secure data and modify the data definition as required.
5. The actual process of analyzing and interpreting data is referred to as _______________.
6. Database consisting of data derived experimentally such as nucleotide sequence and three dimensional structure are known as ____________ .
7. AND, OR, NOT is known as ________________ operator.
8. __________ is defined as the scientific discipline which focuses on the systematic investigation of Genome.
9. ____________ is defined as the use of quantitative protein-level measurements of gene expression in order to characterize biological processes.
10. Gene expression database provide integrated data management and analysis system for the _____________ expression data generated by large-scale gene expression experiments.
11. ____________ increase the query speed.
12. __________ is the process of designing database schemes.
13. Characteristics of an entity is defined by __________ .
14. PDB – tile-encode sequence are __________ .
15. RasMol and VRML are ________ .

1. Write down the difference between Function and Procedure with one example.
2. What is the difference between Database and Database System?
3. Explain Habital Destruction.
4. Write down the advantages of ACeDB for organism Database.

1. What is Nucleotide Sequence Databases and What is its importance?
2. Write shortnote on PDB (Protein data bank).
3. What do you understand by Biological Databases? State its importance.
4. Write a program to find out the number of repeats in a sequence.
5. Define the different types of NCBI databases.

1. the conversion of an amino acid to a keto acid plus ammonia
2. the conversion of an amino acid to a carboxylic acid plus ammonia
3. the transfer of an amino group from an amino acid to a keto acid
4. the transfer of an amino group from an amino acid to a carboxylic acid

2. Which of the following would be an example of the oxidative deamination

1. Glutamate => -Ketoglutarate + NH₃
2. Glutamate => hexanoic acid + NH₃
3. Aspartate + -Ketoglutarate => Glutamate + Oxaloacetate
4. Aspartate + hexanoic acid => Glutamate + Oxaloacetate

3. Transamination is

1. the conversion of an amino acid to a keto acid plus ammonia
2. the conversion of an amino acid to a carboxylic acid plus ammonia
3. the transfer of an amino group from an amino acid to a keto acid
4. the transfer of an amino group from an amino acid to a carboxylic acid

 4. Following statements regarding DNA are true EXCEPT:

1. Attached to the 1' position of the sugar ring is one of four bases.
2. The bases lie stacked on each other 3.4 A apart.
3. The guanine - cytosine bonds are made of two hydrogen bonds.
4. The DNA from a single cell is nearly 2 meters long.

5. The isoelectric point of a protein is defined as

1. the pH at which the net charge on the molecule is 0
2. the pH at which all groups are protonated.
3. the pH at which all groups are unprotonated.
4. the pH at which each acidic group is protonated and each basic group is unprotonated

6. The utilization of ketone bodies would occur in all of the following tissues EXCEPT

1. cardiac muscle.
2. liver.
3. skeletal muscle.
4. brain (adapted to lone-term starvation).

7. The lack of active hypoxanthine-guanine phosphoribosyl transferase causes a human genetic disease known as

1. alkaptonuria.
2. familial hypercholesterolemia.
3. phenylketonuria.
4. Lesch-Nyhan syndrome.

8. Glucose metabolism is necessary in adipose tissue to supply which of the following for the formation of triglycerides

1. ribose 5-phosphate
2. succinyl-CoA
3. alpha-glycerol phosphate
4. phospho-enol-pyruvate

9. All of the following statements about phosphofructokinase 1 (PFK-1) are true EXCEPT

1. it is a major control enzyme in glycolysis.
2. ATP is a substrate for PFK.
3. ATP is a negative effector of PFK.
4. it catalyzes a metabolically irreversible reaction; i.e.,its equilibrium point lies far in one direction.

10. What is the reaction rate in a simple enzymatic system, if the substrate concentration is much less than Km?

1. It would be too slow to measure.
2. It would be reduced by addition of more substrate.
3. It would be uninfluenced by the addition of more substrate.
4. It is virtually proportional to substrate concentration.

1. In muscles and certain other tissues, the amino groups are collected in glutamate by __________.
2. __________ transport the ammonia from muscle to liver.
3. The citric acid cycle is necessary for the urea cycle to continue because it converts__________ to __________, which can then participate in a transamination reaction with glutamate to form aspartate and alpha-ketoglutarate.
4. If glutamate participate in a transamination reaction with__________, the product of the reaction would be alanine and alpha-ketoglutarate.
5. During anaerobic catabolism of a glucose molecule in fermenting yeast _______ ethanol molecules and _______ ATP molecules are produced.
6. During one fatty acid ß-oxidation cycle __________ molecule of FADH2 is produced.
7. The activated precursor during fatty acid synthesis is __________ and during fatty acid degradation the activated intermediate is __________ .
8. Of the three main classes of RNA (rRNA, mRNA, tRNA), __________ the most abundant.
9. Which plays a structural and catalytic role in the ribosome__________ .
10. Which is the most heterogeneous in size__________.
11. The inhibitor appears to be a(n) __________ inhibitor, because Velocity remains low even at very high substrate concentrations.
12. Leu, Ile, Ala are the amino acids with __________side chains.

Write short notes on:

1. Informosomes
2. Biogenesis of mRNA
3. C-DNA
4. ATP
5. Zymogen
6. Cholesterol.
7. Glyoxalate cycle
8. Monosaccharides

1. Distinguish between bases, nucleotides and nucleosides. Give their examples.
2. In what way is anaerobic respiration different from aerobic respiration?
3. What is the net yield of ATP molecules when glycogen rather than glucose is used to produce the glucose phosphate used in cellular respiration.
4. Write notes on :

1. Biological significance of lipids
2. Alpha oxidation of fatty acids

1. What is RNA? Discuss its structure. Give a brief account of different types of RNAs found in the cell.
2. Write short notes on :

1. Michaelis Menten equation
2. Effect of temperature on enzyme activity

1. Write the importance of biochemistry in bioinformatics.
2. Outline the pathway of synthesis of cholesterol from acetate. What are the other biologically important molecules synthesized from cholesterol?

1. Till 2001 how many base pairs have been published in human genome

1. 3000 Mbp
2. 30000 Mbp
3. 300 Mbp
4. 4000 Mbp

2. In TrEMBL annotations are

1. Manual
2. Automated
3. Both a and b
4. None of the above

3. In 1998, Craig Venter started

1. IBM Lifesciences
2. Celera Genomics
3. NCBI
4. GCG

4The size of Haemophilus influenzea is

1. 1.7 Mb
2. 1.8 Mb
3. 1.6 Mb
4. None of the above

5. Human Genome Project was started in

1. 1988
2. 1989
3. 1987
4. 1986

6. HUGO was founded in

1. 1987
2. 1990
3. 1988
4. 1996

7. Caenorshabditis elegans is better known as.

1. Baker’s Yeast
2. Dhobi’s Yeast
3. Former’s Yeast
4. None of the above

8The size of Pseudomonas aeroginosa genome is

1. 6.4 Mbp
2. 6.3 Mbp
3. 6.0 Mbp
4. 6.8 Mbp

9. BLAST program is known as

1. Search tool
2. Search Engine
3. Algorithim
4. Website

10. More’s Law is applied to

1. Biotechnology
2. Physical Electronics
3. Digital Electronics
4. None of the above

1. The two goals that are set for Knowledge Discovery in Databases are ________ and _________.
2. __________is the chain of nucleotide.
3. BLAST is implemented in ________.
4. Full form of EST is ___________.
5. _________ is the alignment algorithms developed by Smith and Smith.
6. FASTA is ________ .
7. Bioinformatics is an integration of __________ and __________ methods to analyze the biological information.
8. Bioinformatics professional should have knowledge of __________ programming language.
9. In 1997, the genome for __________ was published.
10. __________ is the unit of measurement of recombinant frequency on a genetic map.
11. Annotations done in SWISS-PROT are __________.
12. BLAST is implemented in ________.
13. Full form of BIOML is _________.

1. NHGRI
2. NCGR
3. HGSI
4. BEAUTY
5. Bioinformatics
6. DNA
7. Proteins
8. Datamining

1. What is the use of Internet in Bioinformatics?
2. What is difference between Bioinformaticist and Bioinformatician?
3. Write short note on gene annotation?
4. Short Note on Application of Bioinformatics in Genetics.

1. What are web browsers and their role in Science and Technology?
2. Write short note on genome of E.coli.
3. Define the structure of BTIsnet.
4. How can a Bioinformatic company derive benefit from Human genome project?

1. Comments in C++ are started with

1. //
2. {
3. ;
4. :

1. Consider the following section of C++ program, in which i and n are int variables

What are the values of i and n ?

1. i=7 n=8
2. i=7 n=7
3. i=8 n=8
4. i=4 n=7

1. Consider the following section of C++ program, in which i and n are int variables

1. i=9 n=5
2. i=4 n=4
3. i=4 n=5
4. i=5 n=4

1. A compiler produces an error in compiling a program because a closing round bracket has been missed out in the source code. What type of error is this?

1. Syntax Error
2. Logical Error
3. Linker Error
4. Dynamic Error

1. What values can a relational expression take?

1. true and false
2. Any numerical value

1. What values does C++ use to represent true and false ?

1. 1 and 0
2. Any numerical value

1. If x has the value 5.0 what will be the value of the variable countneg after the following piece of C++ is executed?

1. 0
2. 1
3. 5
4. 6

1. If this is changed as follows what would be the value of countneg after execution of the code?

1. 0
2. 1
3. 5
4. 6

1. What is the final value of x if initially x has the value 1?

1. 8
2. 6
3. 1
4. 5

1. What is the final value of x if initially x has the value 0?

if (x >= 0)

x += 5;

if (x >= 5)

x += 2;

1. 7
2. 5
3. 0
4. 8

1. ______________ are the symbolic names used to identify data.
2. ____________ words are identifiers that have special meaning for the compiler.
3. In C++ a char is _____ byte long.
4. In C++ a short integer is at least _____ byte long.
5. An unsigned version of integer can hold numbers in the range of _____ to___________
6. The most commonly used character code is the ____________ code.
7. _____________ is a data form that can hold several values, all of them of one type.
8. _____________ introduce modularity into your program.
9. The program execution always starts with the __________ function.
10. A _____________ groups together data element of different type.
11. _____________ is a sequence of alphanumeric characters enclosed within double quotes.
12. The default access for the members of a class is a _____________.
13. ____________________ the ability of C++ to bundle together data members and methods into a single software unit.
14. ________________ function is a non-member function that is granted access to classes private data members.
15. ______________ is the process of creating new classes from already existing classes.

1. Suppose x is an int variable. Declare a pointer that points to x, and use the pointer to display x value.
2. Write a for loop that prints the values 1 2 4 8 16 32 64 by increasing the value of a counting variable by a factor of 2 each cycle.
3. What are the types of control structure used in describing algorithms?
4. What is a condition?
5. Why may an algorithm be finite and yet impractical to use?
6. How would you endeavour to show that an algorithm you have produced is correct?
7. Write a program, which prompts the user to enter two integer values and a float value and then prints out the three numbers that are entered with a suitable message.
8. Write a ‘for’ statement to output the numbers 1 to 20, each on a new line.

1. What do you understand by inheritance? Explain the role of package and interface in inheritance?
2. What do you understand by data type? What are the three basic data types that Perl uses?
3. What does the following preprocessor directive do?

#include<iostream.h>

4. What distinguishes a Class from Structures?

• Inheritance
• Operator Overloading
• Data Encapsulation and Hiding
• Virtual Function